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Persistent Pulmonary Hypertension of the Newborn (PPHN)

About Pulmonary Hypertension in Newborns

Pulmonary Hypertension

About Pulmonary Hypertension in Newborns

Pulmonary hypertension is a life-threatening syndrome from increased pulmonary vascular resistance (PVR) resulting in restricted blood flow through the pulmonary arterial circulation and ultimately in right heart failure and potentially death. Elevated PVR is also a pre-operative risk factor for morbidities. The absence of pulmonary vasoreactivity is associated with worse prognosis.

Benefits of Nitric Oxide Treatment<sup>1</sup>

Treatment

Benefits of Nitric Oxide Treatment1

Nitric oxide has been used as a long-term therapeutic option for patients with pulmonary hypertension. It was approved in the U.S. by the FDA in 1999 for PPHN, and approved in the EU in 2001 for PPHN and cardiac surgery.2

Inhaled nitric oxide increases the concentration of intracellular Cyclic Guanosine Monophosphate (cGMP) and activates soluble guanylate cyclase. By causing smooth muscle relaxation, nitric oxide treatment increases blood flow to the lungs and decreases the workload on the right ventricle.3

Sources

  1. Pulmonary Hypertension News – “Pulmonary Hypertension and Nitric Oxide”
  2. Nitric Oxide is indicated to improve oxygenation and reduce the need for extracorporeal membrane oxygenation in near-term (>34 weeks gestation) neonates with hypoxic respiratory failure associated with clinical or echocardiographic evidence of pulmonary hypertension in conjunction with ventilatory support and other appropriate agents.
  3. Klinger JR and Kadowitz PJ. The Nitric Oxide Pathway in Pulmonary Vascular Disease. Am J Cardiol. 2017;120(8S):S71-S79.
LungFit PH for Persistent Pulmonary Hypertension of the Newborn (PPHN)

LungFit PH for Persistent Pulmonary Hypertension of the Newborn (PPHN)

On-demand NO generation from ambient air

First truly integrated unit (no need for tanks, cartridges, or cassettes)

Easy to Use

Built in back-up system

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†Caution - LungFit is an Investigational Device, Limited by Federal (or United States) Law to Investigational Use.